I've had good luck with Win32::TieRegistry for working with the Registry on my local machine. The documentation suggests that starting a key with \\remotesysname\... will connect you to a remote system's Registry, but I have not tried it.

The real question in my mind however, is whether you really want the Registry at all. Are you perhaps looking for the Event Log? (I don't have a good answer for reading remote event logs but I think that it is possible.)