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open (FILE, "+<$path/finalgrades.html") or die "Can't open file: $!"; 
+# where $path is the full path to the directory where the file reside
+s.
while (<FILE>) {
  if (m/^<b>[^<>]</b>, grade: (\d+)<br>$/) {
...
  }
}
close (FILE) or die "$!";