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C:\test>junk44
Permission denied : The process cannot access the file because it is b
+eing used by another process at C:\test\junk44.pl line 30.
perl.exe pid: 17320 PB-IM2525-AIO\HomeAdmin :    60: File  (RW-)   C:\
+test\ttz
cmd.exe pid: 17324 PB-IM2525-AIO\HomeAdmin :    60: File  (RW-)   C:\t
+est\ttz
handle.exe pid: 16152 PB-IM2525-AIO\HomeAdmin :    60: File  (RW-)   C
+:\test\ttz

cmd.exe /x/d/c "cmd /c echo xx >$file"

use strict;
use warnings;
...
if( !unlink($file) ) {
    warn $!, ' : ', $^E;
}

## In a different session from which I will run my modified version of
+ your script
C:\test>echo xx > ttz
...
## And back in the first session whilst the 10 second sleep is running
C:\test>handle | find "ttz"
   60: File  (RW-)   C:\test\ttz