I do a lot of projects using the Raspberry Pi and Perl. Most of the time, i use a Perl version i compile into my home directory (/home/cavac/bin/perl-versionnumber/...), as this avoids conflicts with the package managment.

Generally, it works fine on the Pi 2 and Pi 3. I'm using a bunch of these in a cluster to do work on my mesh network code.

Even running PostgreSQL and my Maplat Webserver (written in Perl) on a Raspberry Pi 2 is not a problem. For example, i run my home climate control on one of them (Link may or may not work when you try, this depends on the number of bugs in my DIY DynDNS implementation).

Another RP2 based project runs at my office desk, a status board with 100 RGB LEDs, showing me the statuses of all production lines and my main servers.