Because of the way I learned Perl, I usually edit in my favorite text editor (vim in linux, Notepad++ in windows) and run in the command line, and debug using copious print statements. :-).
But for Windows development, I have followed the advice of Notepad++ Integrated Perl Debugging and occasionally use Notepad++ as a front-end for interactive debug when my print-ing isn't sufficient. There are 32bit and 64bit versions of Notepad++, but the DBGP plugin is only available for the 32bit version. However, I successfully use the 32bit Notepad++ on 64bit Windows on a daily basis, and haven't found any problems. And that setup can call either my 32bit or my 64bit Strawberry Perl, whichever I point it to, so the bitness of the editor doesn't influence the choice in the bitness of the interpreter. But it's a quirky setup, so I wouldn't go so far as to "recommend" it -- I use it, but not always, so it's probably best to just list it as a potential, not the "best" or "recommended".