I currently run Debian almost exclusively, but still like Win(NT|2k).

But before moving from Win32 to Linux, I found that I could customize the Start menu heavily to speed things up by reducing use of mouse.   Create a hiearchical structure of commonly used apps/tools to be accessible from left pinky hit on 'win' key.   Careful naming of said shortcuts for unique first letter then allows you to launch any app/tool by hitting just one one more key, rather than navigating up/down with mouse or arrow keys.

Another technique I used was forced learning of windows keyboard shortcuts.   Disconnect your mouse for one week, and you'll likely find yourself doing the same tasks *much* more quickly.

If you still find yourself pining for *nix but don't want to hassle with dual-boot, many of the popular OpenSource tools/apps (Mozilla, gvim, etc) run on win32. For those that don't, there's always the wholesome goodness of Cygwin, which will even let you run X11.

We all have our own personal preference for pointing devices.   Mine happens to be IBM's trackpoint keyboard.   I *never* have to remove my hands from the touchtyping position, merely use index finger on the eraserhead tucked betwixt g,h,ib keys, and thumbs on "mouse" buttons just below spacebar.   Doubtless not too good for graphic design or such, but for browsing, coding, desktop productivity, I've found nothing else even close for quickness.

Update: triggered by jeffa's node below
I've found OpenOffice v1.0 to be pretty darn good with MS Office files.   Reads and writes my existing Excel and Word files with no hitches, but butchers PowerPoint presentations pretty bad.   Has played a significant factor in keeping my Win2k box cold and dark.

Update B: the win box being a PI/166 while my primary Debian box is a gigahertz Athlon maybe plays a small part too.   Heh.