I generally program it in perl first and see what happens. I have rarely been disappointed :)
In my experience, core perl can be less than optimal for
- Large matrix and vector operations (but see PDL for an excellent speedup)
- Although there are a lot of XS modules out there, interfacing to libraries could be easier.
- Some types of functional programming require efficient handling of tail recursion, which is not a strong point of the current perl.
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