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in reply to Re^2: IO::Socket::UNIX recvmsg error
in thread IO::Socket::UNIX recvmsg error

In this case, FIFOs would actually be more appropriate than sockets. Sockets are analogous to TCP or UDP connections (which is no coincidence), whereas FIFOs are closer to "ordinary" file operations. But since you've already been down that road, you'll have to look elsewhere.

Have you considered processing lines from the file as they arrive, tail -f style?