I just finished with banging my head against the wall over Gtk the other day. It looks nice (better than Tk), but I found it difficult to place widgets (when will there be a Cartesian coordinate widget placing widget set?), the docs are horrific, and there are no good books on Gtk.
Tk isn't much better IMHO. It is still a pain in the ass to use it, not many people use it, and I think it doesn't look so hot.
So what about Glade, huh? Well, I would be lying if I said I wasn't tempted, but it is so...non-Klingon.
redmist
Silicon Cowboy