i agree with jynx, but i'd like to take it a step farther. it would be nice if somehow people could mark themselves as "non-chatters" and have msgs to them give you a warning to that effect.
/msg Dominus Hey Yark! i'll be in your town tomorrow. want to get together and let me buy you lunch?
[_] root says you tried to say "Hey Yark! i'll be in your town tomorrow. want to get together and let me buy you lunch?" to Dominus, but Dominus doesn't chat. You may wish to try other methods.
update: BigJoe suggests that /ignore all and /chatterbox off do what i want, but i've seen nothing indicating that these will warn an errant sender that the target doesn't use the CB. if they do, then i withdraw the request.