You didn't say what you are using in your native environment. Is it Komodo?
I haven't tried Komodo myself, so I don't know how it compares, but Eclipse is an obvious suggestion (that has been made many times over :). It has all the features you enumerate (except maybe programmable macros, but I don't know what you mean by that). The downside is that it's probably on the resource intensive end of the spectrum, though in my experience it performs better on Windows than on Linux (never tried OS/X).
Yeah, there's a Perl plugin called EPIC.
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