open($infile, '<', './file') or die "cannot open file: $!"; binmode $infile; open($outfile, '>', './modifiedfile') or die "cannot open modifiedfile: $!"; binmode $outfile; local $/; $file = <$infile>; $file =~ tr/\FF*{16}//d; print $outfile $file; close ($infile); close ($outfile);