use warnings; use strict; local $/; my $slurp = do { local $/; ; }; print qq{[[$slurp]] \n\n}; my $replace = qq{field2: valueB\n}; my $text = $slurp; $text =~ s{ ^ field1: [^\n]* \n \K (?! ^ \Q$replace\E) .*? (?= ^ field3: [^\n]* \n) } {$replace}xmsg; print qq{[[$text]] \n\n}; $text = $slurp; $text = $text x 100_000; printf qq{length of timing string: %d \n\n}, length $text; print qq{begin timings \n}; my $start = time(); # start timing for replacements $text =~ s{ ^ field1: [^\n]* \n \K (?! ^ \Q$replace\E) .*? (?= ^ field3: [^\n]* \n) } {$replace}xmsg; printf qq{replacements: %ds elapsed \n}, time() - $start; $start = time(); # start timing for no replacements $text =~ s{ ^ field1: [^\n]* \n \K (?! ^ \Q$replace\E) .*? (?= ^ field3: [^\n]* \n) } {$replace}xmsg; printf qq{no replacements: %ds elapsed \n}, time() - $start; print qq{\n}; print substr($text, 0, 250), qq{\n... \n}, substr($text, -250), qq{\n}; __DATA__ yada field1: replace following A some lines here field3: replace previous A blah blah field1: do not replace field2: valueB field3: do not replace field1: replace after B hoo ha fee fie foe field3: replace before B