use IPC::Run3 'run3'; my @command = ('/path/to/python3.7','/path/to/script.py'); my $ret = do { delete local $ENV{LD_LIBRARY_PATH}; my $r; run3 \@command, undef, \$r, \$r or die "run3 failed"; die "command failed, \$?=$?" if $?; $r };