#!/usr/bin/env perl use 5.014; use warnings; use autodie; my $infile = 'pm_11140114_tab_align_even.dat'; my $outfile = 'pm_11140114_tab_align_even.out'; { open my $in_fh, '<', $infile; open my $out_fh, '>', $outfile; while (<$in_fh>) { print $out_fh $_ =~ y/\t/\t/rs; } }