* $seq=IIIIIIIIIIIIIIIMMMMMMMMMMMUUUUUUUUMMMMMMMMMMMMMOOOO
* $seq=IIIIIIIUUUUUIIIIIIIIMMMMMMMMMMMMMMMMMMMMMMMMOOUUUUUUUOO
* $seq=IIIIIIIIIIIIIIIMMMMMMMMMMMMMMMMMMMMMMMMOOUUOO