$ perl -e'
$line   =  "xyz";
$var1   =  "";
$var2   =  "abc";
#check  =  "Yes";


if ( ( ( $line =~ m/$var1/i ) || ( $line =~ m/$var2/i ) ) and ( $check =~ m/YES/i ) ) {
    print "Inside if\n";
    }
else {
    print "Outside if\n";
    }

'
Outside if