$perl{'issues'}->[0]->{'fields'}->{'customfield_22181'};
$perl{'issues'}->[0]->{'fields'}->{'customfield_11150'}->{'value'};
# etc

##</code><code>##

 
#!/usr/bin/perl
use strict;
use warnings;
use feature qw/ say /;
use Data::Dumper;

my %perl = (
    'issues' => [
        {
            'fields' => {
                'customfield_22181' => 'Jira Testing',
                'customfield_11150' => {
                    'value' => 'Yes',
                },
            },
        },
    ],
);

say $perl{'issues'}->[0]->{'fields'}->{'customfield_22181'};
say $perl{'issues'}->[0]->{'fields'}->{'customfield_11150'}->{'value'};

##</code><code>##

Jira Testing
Yes