C:\test\10gb>head data1.txt
@NS500278
GCGCCGGCGGCCATAGGGGCTGGTCAGTAAGAAGTAATGTCCCCAGCTGATTCGGATGGTGCGAATAAGGTCTTATCACTTACCCAAAGTATCTGGCTCTATATTGAGATACCGGAAGCCCCTTGTTGGTACTATGTGATCGATATTTCT
+
=G=C=TATAAA=TGGTTG==C=TAT=GT=C==TAA==CCTA=AAACTTAAG==T=TTTGTCCAGGTAGCGTC=CCA=TG=TA=CT=TT=CC=AA==TCA=ACCGTCGTGGCC=A==GAA=AT=TCAGGCC=CC=GCTAGTG=CCA===TA 1

@NS500278
GTATACCGGTTGAAACAACACGAGAACGAAAGGGTCGCGACTCCATCATAAGGCTAGAAAACCAATTGTATGGATCTGAACATGTTGTGGCGTTACGCGGAACTCCCTGGCTAAAGTGAGACGATTATCAATAGAAAGCAAACTCTACGT
+
AAAC=A=CTC=ATCAA==TGATACCGACCT=CCG=CCAG=CC=G=TC=TGGTG=GAGGTAGGT=AAC=GCACA=CC==GTGGACCCTA=C=C=CG==TA=G=CCA=G==CTGGCGTT=CCGAACAGGC===ATCGATC==TTTCTTTTTT 2