#!/usr/bin/perl -wl use strict; $_ = "3 L-homoserine"; /(\w-\w)/; print $1; s/(\d*\s*)L-homoserine/${1}2-Amino-4-hydroxybutyric acid/; print; $_ = "L-homoserine"; s/(\d*\s*)L-homoserine/${1}2-Amino-4-hydroxybutyric acid/; print; __END__ Prints: L-h 3 2-Amino-4-hydroxybutyric acid 2-Amino-4-hydroxybutyric acid