#!/usr/bin/perl -w
use strict;
use CGI;
use GnuPG;

my $gnupg = new GnuPG(homedir    => '/path/to/home/dir',
                      gnupg_path => '/rath/to/gpg');

# yadda yadda

# and then encrypt someting like this (grabbed from docs, amend to suit...)

$gpg->encrypt(  plaintext   => "file.txt",
                output	    => "file.gpg",
                armor       => 1,
                sign	    => 1,
                passphrase  => $secret);