...
my $argument = something;
my $argument2 = somthing else;
$argument = "'".$argument."'"; #surround in quotes
$argument2 = "'".$argument2."'"; #surround in quotes
$exec_string = "$program $argument $argument2";
system("$exec_string");
...

##</code><code>##

...
$argument=~s/'/'"'"'/g;
...