use Bio::SeqIO; my $instream = Bio::SeqIO->new( -file => 'your_in_file', -format => 'raw' ); my $outstream = Bio::SeqIO->new( -file => '>>your_out_file', -format => 'Fasta' )'; while ( my $sequence = $instream->next_seq() ) { $outstream->write_seq( $sequence ); }