## false if  $ENV{'REQUEST_URI'} contains "FalseIfJustThis"
if($ENV{REQUEST_URI} !~ $regex) { }

## true if $ENV{'REQUEST_URI'} contains "FalseIfJustThis"
##         AND contains "ButIfAlsoThisThenTrue")
if($ENV{REQUEST_URI} =~ $regex and $ENV{REQUEST_URI} =~ $regex2) { }