my @ips = (qw(
    192.168.188.3
    192.168.11.141
    192.168.140.110
    192.168.186.192
    192.168.186.166
    192.168.139.50
    192.168.139.198
    192.168.132.101 ));


my $ignore = join "|", @ips;

while (<FILE>){
   print unless /$ignore/;
}

# -----------------------

sub ignore {
    my $ip = shift;
    for (@ips) {
        return 1 if $ip =~ $_
    }
    return 0;
}

while (<FILE>) {
    print unless ignore($_)
}