my $foo = "12342343432424232"; my $bar = "substr12342343432424232,3,3"; $foo =~ s/(substr($foo,3,3))/fnord/; $bar =~ s/(substr($foo,3,3))/fnord/; print "foo: $foo\n"; print "bar: $bar\n"; #### foo: 12342343432424232 bar: fnord