RewriteRule ^/Something(.*) /path/to/the/main/code.pl

<Directory /path/to/the/main/>
    SetHandler perl-script
    PerlHandler Apache::Registry
    Options ExecCGI
    PerlRequire /path/to/the/main/startup.pl

##</code><code>##

$Apache::Registry::NameWithVirtualHost = 1;

##</code><code>##

Apache::ROOThost_2ename_2ecom::My::Package::_31_2e0::method::handler

##</code><code>##

My::OtherPackage::MyMethod

##</code><code>##

$Apache::Registry::NameWithVirtualHost = 0;