use Mail::Bulkmail /path/to/conf.file

 my $bulk = Mail::Bulkmail->new(
        "LIST"          => "~/my.list.txt",
        "From"          => '"Jim Thomason"<jim@jimandkoka.com>',
        "Subject"       => "This is a test message",
        "Message"       => "Here is my test message"
 ) || die Mail::Bulkmail->error();

 $bulk->bulkmail() || die $bulk->error;