use strict; open(OFILE,">output.txt") or die "Unable to open output file"; open(IFILE,") { print OFILE unless /^CPXX1|^KLXX1|^KMXX1|^MEXX1|^PAXX1|^PMXX1|^SLXX1|^SZXX1|^WXXX1|^YZXX1/ } close(IFILE); close(OFILE);