$_ =<<SQ;
ATOM   3316  N   TYR D  24      97.479  18.805   2.990  1.00 36.32      D    N
ATOM   3322  CD1 TYR D  24      96.225  15.974   2.812  1.00 17.96      D    C
SQ

s/(?<!CD1 \s TYR \s)(\b D \b)/X/gx;

__END__

STDOUT:
ATOM   3316  N   TYR X  24      97.479  18.805   2.990  1.00 36.32      X    N
ATOM   3322  CD1 TYR D  24      96.225  15.974   2.812  1.00 17.96      X    C