my $data =">DL;H1_ENSP00000194530_chr2_202024 CCCC---GCCTTCTCGCTGCCCAGC--CCCGGGGAGGGAGG*";

$data =~ s/[-*]|DL;//g;  # globaly, replace all "-" or "*" OR "DL;" with nothing
                         # ignores possibility "DL;" appears elsewhere in data
                         # if that's an issue, you might want to do two substitutions
                         # $data =~ s/[-*]//g;  and $data =~ s/(>)DL;/$1/g;
                         # though that last is NOT tied to the beginning of the line
                         # which appears to be subject to brain_block at the moment
print $data;

=head OUTPUT

perl dataclean.pl
>H1_ENSP00000194530_chr2_202024 CCCCGCCTTCTCGCTGCCCAGCCCCGGGGAGGGAGG

=cut