sub canonize { return join '', sort split //, lc $_[0]; }

my %dict;
{
   open(my $fh, '<', $dict_file)
      or die("Unable to open dictionary file \"$dict_file\": $!\n");

   while (<$fh>) {
      chomp;
      push @{ $dict{canonize($_)} }, $_;
   }
}

my $jumble = 'OLHOSC';

$jumble = canonize($jumble);
if (exists($dict{$jumble})) {
   print("$_\n") for @{ $dict{$jumble} };
} else {
   print("No matches found.\n");
}