use Win32::Event qw[ wait_any ];

...
my $notifyFileName = Win32::ChangeNotify->new($path, $subtree, 'FILE_NAME' );
my $notifyLastWrite = Win32::ChangeNotify->new($path, $subtree, 'LAST_WRITE' );

my @nfys = ( $notifyFileName, $notifyLastWrite );

defined( my $signalled = wait_any( @notify, $timeout ) ) 
    or die "Mutex error: $^E";

if( $signalled == 1 ) {
    ## Look for fine name change
}
elsif( $signalled == 2 ) { 
   ## Look for last write change
}
elsif( $signalled < 0 ) {
    warn "Abaindoned mutex"; ## ?
}
else {
    ## Wait timed out (only if timeout used)
}