use strict; my %charmap = ( A => '00', C => '01', G => '10', T => '11', ); my $string = 'GATTACA'; $string =~ s/(.)/$charmap{$1}/ge; print "$string\n"; my $compressed = pack 'b*', $string; print "$compressed\n"; printf "%d bytes\n", length $compressed; # now use vec() to get at the single parts of $compressed my $decompressed = unpack 'b*', $compressed; print "$decompressed\n";