...
LINE: while (<$fh>) {

    if ($aquiSW =~ /New Stuff/i) {
        next LINE unless /1$/;
    }

    if ($lA && $Artist ne ".*") {
        next LINE unless /^\Q$Artist/i;
    }

    if ($lL && $Label ne "*") {
        next LINE unless /\|\Q$Label/i;
    }

    # ...

    if ($lT && $Title ne "*") {
        # split $Title into @words...
  
        for my $word (@words) {
            next LINE unless /\Q$word/i;
        }
    }

    # ...
        
    # we only get here if all the tested conditions matched
    print;
}