2011-01-30 17:21:25.990853 IP 10.10.10.53.2994 > 205.128.64.126.80
.!)~.....Bb...E..(l8@...lZ

2011-01-30 17:21:26.056348 IP 10.10.10.53.2994 > 205.128.64.126.80
GET /j/MSNBC/Components/Photo/_new/110120-durango_tease.thumb.jpg HTTP/1.1
Accept: */*
Accept-Encoding: gzip, deflate
User-Agent: Mozilla/4.0 (compatible; MSIE 7.0; Windows NT 5.1; Trident/4.0; InfoPath.2)

2011-01-30 17:21:26.078293 IP 205.128.64.126.80 > 10.10.10.53.2994
...Bb..!)~....E....L../.....@~

##</code><code>##

open FILE, "<", "filename.txt" or die $!
while (<FILE>) {
    if (($_ =~ /^$year\-/) && ($_ =~ /\Q $IP1 \E/) && ($_ =~ /\Q $IP2 \E/)) { print "packet match found!"; }
}