perl Makefile.PL --testdb=test --testuser=root --testpassword=<password> --libs='-L/opt/local/lib -L/opt/local/lib/mysql5/mysql -lmysqld -ldl -L/opt/local/lib -lz -lm -L/opt/local/lib/ -lssl -lcrypto' --mysql_config=/opt/local/lib/mysql5/bin/mysql_config

##</code><code>##

I will use the following settings for compiling and testing:

  cflags        (mysql_config ) = -I/opt/local/include/mysql5/mysql  -pipe -fPIC -m64   -D_P1003_1B_VISIBLE -DSIGNAL_WITH_VIO_CLOSE -DSIGNALS_DONT_BREAK_READ -DIGNORE_SIGHUP_SIGQUIT  -DDONT_DECLARE_CXA_PURE_VIRTUAL
  embedded      (mysql_config ) = 
  libs          (User's choice) = -L/opt/local/lib -L/opt/local/lib/mysql5/mysql -lmysqld -ldl -L/opt/local/lib -lz -lm -L/opt/local/lib/ -lssl -lcrypto
  mysql_config  (Users choice ) = /opt/local/lib/mysql5/bin/mysql_config
  nocatchstderr (default      ) = 0
  nofoundrows   (default      ) = 0
  ssl           (guessed      ) = 1
  testdb        (User's choice) = test
  testhost      (default      ) = 
  testpassword  (User's choice) = <password>
  testsocket    (default      ) = 
  testuser      (User's choice) = root

To change these settings, see 'perl Makefile.PL --help' and
'perldoc INSTALL'.

Checking if your kit is complete...
Looks good
Using DBI 1.615 (for perl 5.012003 on darwin-thread-multi-2level) installed in /System/Library/Perl/Extras/5.12/darwin-thread-multi-2level/auto/DBI/
Writing Makefile for DBD::mysql
Writing MYMETA.yml and MYMETA.json

##</code><code>##

cp lib/DBD/mysql.pm blib/lib/DBD/mysql.pm
cp lib/DBD/mysql/GetInfo.pm blib/lib/DBD/mysql/GetInfo.pm
cp lib/DBD/mysql/INSTALL.pod blib/lib/DBD/mysql/INSTALL.pod
cp lib/Bundle/DBD/mysql.pm blib/lib/Bundle/DBD/mysql.pm
llvm-gcc-4.2 -c  -I/System/Library/Perl/Extras/5.12/darwin-thread-multi-2level/auto/DBI -I/opt/local/include/mysql5/mysql  -pipe -fPIC -m64   -D_P1003_1B_VISIBLE -DSIGNAL_WITH_VIO_CLOSE -DSIGNALS_DONT_BREAK_READ -DIGNORE_SIGHUP_SIGQUIT  -DDONT_DECLARE_CXA_PURE_VIRTUAL -DDBD_MYSQL_WITH_SSL -DDBD_MYSQL_INSERT_ID_IS_GOOD -g  -arch x86_64 -arch i386 -g -pipe -fno-common -DPERL_DARWIN -fno-strict-aliasing -fstack-protector -I/usr/local/include -Os   -DVERSION=\"4.021\" -DXS_VERSION=\"4.021\"  "-I/System/Library/Perl/5.12/darwin-thread-multi-2level/CORE"   dbdimp.c
dbdimp.c: In function ‘mysql_describe’:
dbdimp.c:3609: warning: assignment from incompatible pointer type
dbdimp.c: In function ‘mysql_describe’:
dbdimp.c:3609: warning: assignment from incompatible pointer type
lipo: /var/folders/v1/hy10rvls1dbdw7k_0gqgmn8r0000gn/T//cczrvzA1.out and /var/folders/v1/hy10rvls1dbdw7k_0gqgmn8r0000gn/T//ccpdhjjg.out have the same architectures (x86_64) and can't be in the same fat output file
make: *** [dbdimp.o] Error 1