use Win32::OLE qw(in with);
use Win32::OLE::Const 'Microsoft Word';
    
$Win32::OLE::Warn = 2; # Throw Errors, I'll catch them

my $Word = Win32::OLE->GetActiveObject('Word.Application')
    || Win32::OLE->new('Word.Application', 'Quit');

my $Doc = Win32::OLE->GetObject($wrdfile) || die &CheckError(); 

#### or ####

my $Doc = $Word->Documents->Open($wrdfile) || die &CheckError();