use strict; use warnings; open(my $N148,'<',"148Nsorted.bed") or die $!; open(my $N162,'<',"162Nsorted.bed") or die $!; open(my $N174,'<',"174Nsorted.bed") or die $!; open(my $N175,'<',"175Nsorted.bed") or die $!; my ($chr148, $start148, $end148) = scan($N148); my ($chr162, $start162, $end162) = scan($N162); my ($chr174, $start174, $end174) = scan($N174); my ($chr175, $start175, $end175) = scan($N175); my ($minstart, $maxstart, $minend, $maxend); while(defined($chr148)) { $minstart = $start148; $maxstart = $start148; $minend = $end148; $maxend = $end148; while(defined($chr162) and $chr162 lt $chr148) { ($chr162, $start162, $end162) = scan($N162); } while(defined($chr162) and $chr162 eq $chr148) { $minstart = $start162 if($start162 < $minstart); $maxstart = $start162 if($start162 > $maxstart); $minend = $end162 if($end162 < $minend); $maxend = $end162 if($end162 > $maxend); if($maxstart <= $minend) { while(defined($chr174) and $chr174 lt $chr148) { ($chr174, $start174, $end174) = scan($N174); } while(defined($chr174) and $chr174 eq $chr148) { $minstart = $start174 if($start174 < $minstart); $maxstart = $start174 if($start174 > $maxstart); $minend = $end174 if($end174 < $minend); $maxend = $end174 if($end174 > $maxend); if($maxstart <= $minend) { while(defined($chr175) and $chr175 lt $chr148) { ($chr175, $start175, $end175) = scan($N175); } while(defined($chr175) and $chr175 eq $chr148) { $minstart = $start175 if($start175 < $minstart); $maxstart = $start175 if($start175 > $maxstart); $minend = $end175 if($end175 < $minend); $maxend = $end175 if($end175 > $maxend); if($maxstart <= $minend) { print "$chr148 $minstart $maxend\n"; } ($chr175, $start175, $end175) = scan($N175); } } ($chr174, $start174, $end174) = scan($N174); } } ($chr162, $start162, $end162) = scan($N162); } ($chr148, $start148, $end148) = scan($N148); } close($N148); close($N162); close($N174); close($N175); exit(0); sub scan { my ($fh) = @_; my $line = <$fh>; return() unless($line); return(split(/\t/, $line)); } #### use strict; use warnings; use List::Util qw(min max); my $ranges148 = scan('148Nsorted.bed'); my $ranges162 = scan('162Nsorted.bed'); my $ranges174 = scan('174Nsorted.bed'); my $ranges175 = scan('175Nsorted.bed'); foreach my $chr (keys %$ranges148) { foreach my $range148 (@{$ranges148->{$chr}}) { foreach my $range162 (@{$ranges162->{$chr}}) { foreach my $range174 (@{$ranges174->{$chr}}) { foreach my $range175 (@{$ranges175->{$chr}}) { my $minstart = min( $range148->[0], $range162->[0], $range174->[0], $range175->[0]); my $maxstart = max( $range148->[0], $range162->[0], $range174->[0], $range175->[0]); my $minend = min( $range148->[1], $range162->[1], $range174->[1], $range175->[1]); my $maxend = max( $range148->[1], $range162->[1], $range174->[1], $range175->[1]); if($maxstart <= $minend) { print "overlapping $chr: $minstart, $maxend - ($range148->[0], $range148->[1]), ($range162->[0], $range162->[1]), ($range174->[0], $range174->[1]), ($range175->[0], $range175->[1])\n"; } else { print "not overlapping: $chr: $minstart, $maxend - ($range148->[0], $range148->[1]), ($range162->[0], $range162->[1]), ($range174->[0], $range174->[1]), ($range175->[0], $range175->[1])\n"; } } } } } } exit(0); sub scan { my ($file) = @_; open(my $fh, '<', $file) or die "$file: $!"; my $ranges; foreach my $line (<$fh>) { chomp($line); my ($chr, $start, $end) = split(/\t/, $line); push(@{$ranges->{$chr}}, [ 0+$start, 0+$end ]); } return($ranges); }