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my $q1s = join('|', @matchwords);
my $q1  = qr/$q1s\s*\w+/;

my $q3s = join('|', @matchwords);
my $q3  = qr/($q3s)\\s*\\w+/;

alternation, grouping:  1 wallclock secs ( 0.58 usr +  0.00 sys =  0.5
+8 CPU) @ 1724137.93/s (n=1000000)
alternation, no grouping:  5 wallclock secs ( 4.85 usr +  0.00 sys =  
+4.85 CPU) @ 206185.57/s (n=1000000)
loop, grouping: 24 wallclock secs (23.33 usr +  0.00 sys = 23.33 CPU) 
+@ 42863.27/s (n=1000000)
loop, no grouping: 23 wallclock secs (22.57 usr +  0.00 sys = 22.57 CP
+U) @ 44306.60/s (n=1000000)