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$changeme = "/this/url/would/be/a/nightmare/in/regex/";
$changeme =~ s#would/be#is/not#;

$changeme = "/this/url/wo*ld/b^e/a/nightmare/in/regex/";
$changeme =~ s/\Qwo*ld/b^e\E/\Qis/not\E/;