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INSERT INTO data (skey, svalue) VALUES ('Stuff', 'Ge 1:1-more &stuff& 
+here ');

$dbh->do("INSERT OR REPLACE INTO data (skey, svalue) VALUES ('Stuff', 
+'Ge 1:1-more &stuff& here ''');");

$VAR1 = {
          'Stuff' => {
...
                       'skey' => 'Stuff'
                     }
        };

$dbh->do(
    q/INSERT OR REPLACE INTO data (skey, svalue) VALUES ('Stuff', 'lit
+eral dollar sign: $, literal single quote: '', literal ampersand: &')
+;/
);

my $sth = $dbh->prepare(
    'INSERT OR REPLACE INTO data (skey, svalue) VALUES (?, ?);'
...
$sth->bind_param(1, $skey);
$sth->bind_param(2, $svalue);
$sth->execute();