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AIX 4.1.[45], 4.2[.1], and 4.3[.123]
BSDI BSD/OS 2.1, 3.[01], and 4.[01] for Intel-based systems
...
Solaris 2.5.1, 2.6, 7, 8 BETA, and 8 BETA-Refresh
SunOS 4.1.x
Ultrix 4.2

open(LSOF,"/usr/sbin/lsof MY_OPTIONS_HERE |") || die $!;
while(<LSOF>) {
    # so stuff
}

@output = `/usr/sbin/lsof MY_OPTIONS_HERE`;