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#!/usr/bin/perl -w

...
timethese(1E6, {
   'nospace' => sub { grep {/$nsre/} @data; },
   'isspace' => sub { grep {!/$isre/} @data; }})

Benchmark: timing 1000000 iterations of isspace, nospace...
   isspace: 67 wallclock secs (56.34 usr +  0.15 sys = 56.49 CPU) @ 17
+702.25/s (n=1000000)
   nospace: 63 wallclock secs (49.19 usr +  0.26 sys = 49.45 CPU) @ 20
+222.45/s (n=1000000)