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  $obj->thing(15000, 20000) =~ s[something][else]g;

  $spreadsheet->cell('C3', 'D4') =~ s[something][else]g;

  # current lvalue sub:
  (my $val = $spreadsheet->cell('C3', 'D4')) =~ s[something][else]g;
...
  # without lvalue sub:
  (my $val = $spreadsheet->cell('C3', 'D4')) =~ s[something][else]g;
  $spreadsheet->cell('C3', 'D4', $val);