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# URL for primer3
my $url = 'http://frodo.wi.mit.edu/cgi-bin/primer3/primer3_www.cgi';

...

print "\n\n******* AND Response *********\n\n";
print $resp->content();

Did not see the 'Pick Primers' query parameter at /usr/local/apache2/c
+gi-bin/primer3/primer3_www_results.cgi line 117
        main::main() called at /usr/local/apache2/cgi-bin/primer3/prim
+er3_www_results.cgi line 105

  if ($query->param('Pick Primers')) {
      process_input($query);
  } else {
      confess "Did not see the 'Pick Primers' query parameter"
  }