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# @ins is actually calculated at runtime. 
# Defined here for demonstration.
...
my $in = join ', ', @ins;
my $sth = $dbh->prepare("SELECT foo FROM Bar WHERE baz IN ( ? )");
$sth->execute( $in );

my @ins = qw(1 2 3 4 5 6);
my $in;  $in .= '?, ' for @ins;
...
$in =~ s/, $//;
my $sth = $dbh->prepare("SELECT foo FROM Bar WHERE baz in ( $in )");
$sth->execute( @ins );