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While it's possible with system() to run command
with custom filehandles instead of inheriting only
...
 - No signal handling at all, so all open() limitations about
   SIGCHLD, SIGINT, SIGQUIT and SIGPIPE apply.
 - You can't interact with running command using pipes.

Limitations of other modules from reliability/security view:

...
 - Doesn't handle SIGCHLD, SIGINT, SIGQUIT.

=back