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my $state;

...
    print $line unless $state eq "COMMENT";
}

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07:37<sandvik@sat1> ~/perl$ ./pmtest.pl
LOCUS       4                     302276 bp    DNA     linear   HTG 31
+-OCT-2008
...
                     /gene="ENSMUSG00000070661"
                     /note="ring finger protein 186 [Source:MGI;Acc:MG
+I:1914075]