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#I want to remove this line.
#"#This line too"
...
puts "############I don't want to remove this content bcoz it is in qu
+otes#"  #But remove this content.
puts "This is for testing ##sdfsfsf"  ###Remove this content.
puts 'This is for testing ##testing' #I want to remove this content al
+one'

I have tried the following expression,

...
     $_ =~ s/([^"|'](#)+.*[^"|'])\s*#.*$/$1/;
     $_ =~ s/[^"|']#.*[^"|']$//;

Desired output:
puts "Hello, Ruby!" ",,,,,....'''"
puts "############I don't want to remove this content bcoz it is in qu
+otes#"
puts "This is for testing ##sdfsfsf"
puts 'This is for testing ##testing'